Modern society requires us to be performing, fast and efficient on a daily basis, but much of the time we risk, or sometimes actually reach, a state of collapse, over-exhaustion or even total burnout. Fatigue covers a wide range of disorders related to physical, psychological and social problems. Intense fatigue is estimated to affect 25% of people, with CFS (Chronic Fatigue Syndrome) at 3.28%. A higher percentage is seen among the population aged between 40-59. Fatigue can affect any ethnic or socioeconomic group, and any gender, although women are affected up to 4 times the rate of men. Until now, little progress has been made in understanding and treating CFS, and no specific drug is yet available.
As a result, a plethora of "tonics", "restoratives" and "adaptogenic" supplements have appeared on the market, often handed down by the tradition of Oriental medicine. Some of these do have real scientific foundations, which really are effective in helping to prevent or recover from states of severe fatigue, while others are more hype than substance, and their only effect is on your wallet.
QUERVIT is a new "adaptogenic" supplement consisting of Robuvit®, a patented, standardized oak extract developed by Horphag Research (the same producers as Pycnogenol®). Robuvit® is a powerful ingredient of guaranteed high quality, which offers very interesting health benefits, as confirmed by a number of scientific studies. Thanks to its unique properties, Robuvit® has demonstrated, through multiple international clinical studies, that it can be a powerful aid for health by energizing the body and encouraging detoxification. In view of this great potential, further in-depth studies are still in progress on this extraordinary French extract and its significant reinvigorating, detoxifying power.
This is no magic cure-all with a purely commercial purpose. The decision to use Robuvit® is strongly supported by the fact that the product actually works. Recently, important confirmation as to its real effectiveness as come from a growing body of scientific literature, thanks to the special "roburine" bioflavonoids which have a powerful bioactive effect on the body. Robuvit® oak extract comes from France, where the oak trees are grown in the forest of the Massif Central region, under strict sustainability regulations. The trees are grown without any fertilizers, pesticides or herbicides. Robuvit® is extracted in water from the oak wood, as part of a safe, environmentally friendly production process.
Robuvit® offers a solution, based on important scientific evidence and which is safe and completely natural, to increase energy, reduce fatigue and improve both physical performance and mood like few other supplements in its category. Numerous clinical studies have shown that Robuvit® can actually help with CFS (Chronic Fatigue Syndrome), the symptoms of which include loss of memory or concentration, muscle pain, headache, non-restorative sleep, dizziness, allergies and mood swings, and it can also help physical performance. Scientific literature has reported that Robuvit® provides benefits in various areas such as liver function, as an excellent detoxifier, in blood glucose control, improvement of lymphatic function, control of homocysteine level (a cardiovascular risk factor) and has other benefits that are still being studied.
Its main effect is its capacity to produce energy, which it does without impacting the nervous system in terms of tachycardia, agitation or sudden changes in blood pressure.
QUERVIT is a new generation adaptogen that counteracts chronic fatigue, a disorder that has many different aspects and is often misinterpreted and can be highly debilitating. Chronic fatigue can affect anyone in different periods of their life, causing a multitude of complaints ranging from non-restorative sleep to a lack of energy, apathy, or muscle fatigue when performing simple activities; it also has various other symptoms that do not currently have well-defined treatment rules.
But how does it work?
Energy in the body is generated by mitochondria, which are largely organelles of small autonomous cells, present in all the cells of the body. These "power plants" generate energy in the form of ATP, by burning nutrients, carbohydrates, lipids and other materials. A byproduct of this is considerable oxidative stress, which can damage the host cell, and in particular the mitochondria. Ageing mitochondria continue to process fats and carbohydrates, but their efficiency rapidly decreases due to the generation of ATP and the buildup of oxidative stress and detritus that gradually destroys the mitochondrion. Organs with a high energy turnover such as muscles, neurons and the liver, are particularly prone to damage.
The metabolites of Robuvit® urolithins are indicated for inducing mitophagy, a process that subjects the old, burned-out, dysfunctional mitochondria to lysosomes, parts of the cell that specialise in the complete disintegration of debris, enzymes and acid. Instead, new, fully-functional mitochondria are formed, which maximises the energy yield. And you can feel it! Robuvit® metabolites increase muscle function by rejuvenating the mitochondria through the accelerated replacement of newly-synthesized, fully-functioning mitochondria resulting in a more efficient energy yield.
Robuvit® can also support protein synthesis and the production of microchondrial energy, which implies substantial support for liver function. Eleven clinical studies have shown it to be of benefit for people at all stages of life.
In this regard Robuvit® significantly increases the performance of athletes, as confirmed by three studies that have identified energizing effects with significant improvements in endurance, for people suffering from chronic fatigue. Four studies indicate significant support for liver health, which opens up prospects for use of Robuvit® in detoxifying the liver. As we know, the liver is the largest gland in the human body, and is essential for the metabolism. It is connected to the digestive system, and performs multiple functions not only useful for digestion, but also for the body's defence and for eliminating toxins, as it contains the largest agglomeration of enzymes to synthesize, modify and degrade substances as required.
Clinical investigations have also shown that daily supplementation with Robuvit® significantly reduces harmful homocysteine levels. High levels of homocysteine indicate concerns about liver health due to an unhealthy diet or intake. Increased homocysteine levels can cause inflammation of the blood vessels, and may ultimately be a risk factor for cardiovascular disease. Supplementation with Robuvit® significantly lowers homocysteine levels in individuals with high levels of this harmful substance, which has recently emerged as a topic of discussion in the medical field.
Recent research has highlighted a very interesting factor that points to Robuvit®'s great power during convalescence. The study demonstrated a strongly accelerated recovery time and a capacity to boost the body's defences after the immune system has been weakened by fighting a virus. In particular, a new study published in the Journal of Sports Medicine and Physical Fitness shows that taking Robuvit® the day after the disappearance of flu symptoms can help improve recovery from the illness. The study tested 38 patients aged 65 to 75 who had been diagnosed with influenza.
After three weeks, the participants who completed the Robuvit® study reported surprising results, with better recovery than the control groups, including:
- Increased post-flu strength THIS MAKES NO SENSE (should be the other way round 85% Robuvit against 60% in the control group)?
- Enhanced recovery after exertion (64 percent Robuvit group / 48 percent of the control group)
- Significant improvement in attention (82% of Robuvit group / 30% of the control group)
- Better quality of sleep (83% Robuvit group / 59% control group)
- Improvement of work capacity and concentration (82% of Robuvit group / 31% control group)
We have all heard of restorative supplements, but usually with a general, unspecific or poorly-defined effect. They tend to be combined with vitamins or other immuno-modulating substances, as there is not a large market for recovery from influenza. Most options on the market are for the prevention of influenza, but recovery is an equally important, and often over-overlooked aspect of influenza illnesses. It is especially important for the elderly, who have weakened immune systems and who are at risk of developing other disorders or complications during their recovery.
Scientific literature also extends to sportspeople, and support for endurance athletes. It has emerged that taking 300 mg a day during two weeks of training significantly shortened marathon and triathlon finishing times, by reducing the level of free radicals in plasma one hour post-exercise, and by protecting blood cells from haemolysis, with a noticeable extension of fatigue resistance and improved performance.
According to oral toxicity studies, Robuvit® supplementation is completely safe, and is compatible with all other nutritional supplements. No side effects have been observed during clinical trials.
The average dosage is one vegetal capsule containing 100 mg of Robuvit®, taken once or twice a day. In states of persistent chronic fatigue, mainly related to oxidative stress, treatment will take three to six months.
References
Improvement in mood, oxidative stress, fatigue, and insomnia following supplementary management with Robuvit®.
Belcaro G, Saggino A, Cornelli U, Luzzi R, Dugall M, Hosoi M, Feragalli B, Cesarone MR. J Neurosurg Sci. 2018 Aug
Supplementation with Robuvit® in post-mastectomy post-radiation arm lymphedema.
Belcaro G, Dugall M, Cotellese R, Feragalli B, Cianchetti E, Cesarone MR. Minerva Chir. 2018 Jun
Temporary kidney dysfunction: Robuvit® supplementation in initial, transient kidney insufficiency and micro-macro albuminuria.
Ledda A, Belcaro G, Feragalli B, Hosoi M, Cacchio M, Luzzi R, Dugall M, Cotellese R, Cesarone MR. Panminerva Med. June 2018
Robuvit®: improvement of fatigue in medical convalescence.
Ippolito, Belcaro, Luzzi, Hosoi, Dugall, Rohdewald, Feragalli, Cotellese, Peterzan. J Sports Med Phys Fitness. May 2018
Supplementary management of functional, temporary alcoholic hepatic damage with Robuvit® (French oak wood extract).
Pellegrini L, Belcaro G, Dugall M, Corsi M, Luzzi R, Hosoi M. Minerva Gastroenterol Dietol. 2016 Mar 3.
Robuvit® and endurance in triathlon: improvements in training performance, recovery and oxidative stress.
Vinciguerra MG, Belcaro G, Cacchio M. Minerva Cardioangiol. 2015 Oct;63(5):403-9.
An Effect of Oak-Wood Extract (Robuvit®) on Energy State of Healthy Adults-A Pilot Study.
Országhová Z, Waczulíková I, Burki C, Rohdewald P, Duracková Z. Phytother Res. 2015 Aug;29(8):1219-24. doi: 10.1002/ptr.5368. Epub 2015 May 18.
French Oak Wood (Quercus robur) Extract (Robuvit®) in Primary Lymphedema: A Supplement, Pilot, Registry Evaluation.
Belcaro G, Dugall M, Hu S, Ledda A, Ippolito E. Int J Angiol. 2015 Mar;24(1):47-54. doi: 10.1055/s-0034-1395982.
Robuvit® (Quercus robur extract) supplementation in subjects with chronic fatigue syndrome and increased oxidative stress. A pilot registry study.
Belcaro G, Cornelli U, Luzzi R, Ledda A, Cacchio M, Saggino A, Cesarone MR, Dugall M, Feragalli B, Hu S, Pellegrini L, Ippolito E. J Neurosurg Sci. 2015 Jun;59(2):105-17. Epub 2014 Nov 14.
Influence of oak wood polyphenols on cysteine, homocysteine and glutathione total levels and PON1 activities in human adult volunteers - a pilot study.
Deáková Z, Országhová Z, Andrezálová L, Slezák P, Lehotay J, Muchová J, Bürki C, Duracková Z. Gen Physiol Biophys. 2015 Jan;34(1):73-80. doi: 10.4149/gpb_2014029. Epub 2014 Nov 4.
Effect of the French oak wood extract Robuvit® on markers of oxidative stress and activity of antioxidant enzymes in healthy volunteers: a pilot study.
Horvathova M, Orszaghova Z, Laubertova L, Vavakova M, Sabaka P, Rohdewald P, Durackova Z, Muchova J. Oxid Med Cell Longev. 2014;2014:639868. doi: 10.1155/2014/639868. Epub 2014 Aug 31.
Robuvit® (French oak wood extract) in the management of functional, temporary hepatic damage. A registry, pilot study.
Belcaro G, Gizzi G, Hu S, Dugall M, Pellegrini L, Cornelli U, Cesarone MR, Trignani M, Maione C. Minerva Med. 2014 Feb;105(1):41-50.
Absorption, metabolism, and effects at transcriptome level of a standardized French oak wood extract, Robuvit®, in healthy volunteers: pilot study.
Natella F, Leoni G, Maldini M, Natarelli L, Comitato R, Schonlau F, Virgili F, Canali R. J Agric Food Chem. 2014 Jan 15;62(2):443-53. doi: 10.1021/jf403493a. Epub 2014 Jan 6.
Improved management of primary chronic fatigue syndrome with the supplement French oak wood extract (Robuvit®): a pilot, registry evaluation.
Belcaro G, Cornelli U, Luzzi R, Cesarone MR, Dugall M, Feragalli B, Hu S, Pellegrini L, Ippolito E. Panminerva Med. 2014 Mar;56(1):63-72. Epub 2013 Nov 14.
Directions: take 1 tablet a day, with water.
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