YAMAMOTO RESEARCH
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 YAMAMOTO® RESEARCH
Yamamoto® Research Vitamin B12 But what is the peculiarity of Vitamin B12 Yamamoto® Research? Yamamoto®'s mission is to create supplements that are of the highest scientific efficacy, and in this case too we wanted to offer a "plus". It is called "methylcobalamin", and it is a methylated and decidedly more absorbable form of cobalamin (vitamin B12), with the result that taking even a lower dosage will result in greater bioavailability, reaching "destination" where it is needed. When adequate levels of this cobalamin or vitamin B12 are maintained, maximum expression of this will be achieved, supporting the nervous, immune and circulatory systems. Due to its direct brain-passing effect, this supplement can help increase mental functions such as memory and attention, with an improvement in general well-being. Here is quickly explained why these supplements are called "tonics". It has also been noted that methylcobalamin indirectly helps regulate sleep cycles and circadian rhythms in the body. Another very curious and important benefit that comes from an adequate intake of this methylcobalamin compound is that it can help protect the body from harmful toxins. The presence of choline bitartrate and inositol will further support liver function, in the important detoxification processes (from methylation) that the B complex assists and in the metabolism of fats and cholesterol. Vitamin B12 is an essential vitamin that our body is unable to produce and that must be introduced by food, and it is a water-soluble vitamin that is part of the complex of B vitamins. Its complex structure is characterized in the center , from the presence of a cobalt atom, to which it owes the name of "cobalamin". We commonly find it in very small quantities in a variety of foods of animal origin such as fish, crustaceans, meat (particularly "red" ones) and in dairy products. Vitamin B12 physiologically plays very important roles for the correct functioning of the physiology of our body, helping to keep nerve cells and red blood cells healthy and efficient, and is necessary to synthesize DNA, our genetic material present in all cells. Vitamin B12 is normally bound to food proteins and the acidic environment present inside the stomach allows it to be separated during the digestion process. The action of gastric juices and in particular the secretion of intrinsic factor by the cells of the gastric wall is essential for the subsequent absorption of vitamin B12 in the intestine. Specifically, the "most famous" of the B complex vitamins, serves for the correct physiology of the structure and functionality of red blood cells, intervening in the process of their synthesis by the bone marrow, supporting the synthesis of hemoglobin and DNA being a fundamental cofactor of methionine synthase, an enzyme involved in the synthesis of purines and pyramidines, the nitrogenous bases that make up nucleic acids (DNA and RNA). Vitamin B12 is necessary for the metabolism of the central nervous system. On an aesthetic level, Vitamin B12 has a positive effect on the health of the skin, hair, and nails. Vitamin B12 is absorbed into the body through the stomach, combines with a protein substance called intrinsic factor, which is produced in the stomach and absorbed by the food you eat. Vitamin B12 deficiency is very common in older people, affecting one in 10 people over the age of 75. It is less common in young people, although those who follow a vegan diet are more likely to have this deficiency, as vitamin B12 is found mainly in foods of animal origin. SCIENTIFIC REFERENCES: O'Leary F, Samman S. Vitamin B12 in health and disease. Nutrients. 2010 Mar;2(3):299-316. doi: 10.3390/nu2030299. Epub 2010 Mar 5. PMID: 22254022; PMCID: PMC3257642. Oh R, Brown DL. Vitamin B12 deficiency. Am Fam Physician. 2003 Mar 1;67(5):979-86. PMID: 12643357. Shipton MJ, Thachil J. Vitamin B12 deficiency - A 21st century perspective . Clin Med (Lond). 2015 Apr;15(2):145-50. doi: 10.7861/clinmedicine.15-2-145. PMID: 25824066; PMCID: PMC4953733. Gille D, Schmid A. Vitamin B12 in meat and dairy products. Nutr Rev. 2015 Feb;73(2):106-15. doi: 10.1093/nutrit/nuu011. PMID: 26024497. Clementz GL, Schade SG. The spectrum of vitamin B12 deficiency. Am Fam Physician. 1990 Jan;41(1):150-62. PMID: 2278533. Hvas AM, Nexo E. Diagnosis and treatment of vitamin B12 deficiency--an update. Haematologica. 2006 Nov;91(11):1506-12. Epub 2006 Oct 17. PMID: 17043022. Baik HW, Russell RM. Vitamin B12 deficiency in the elderly. Annu Rev Nutr. 1999;19:357-77. doi: 10.1146/annurev.nutr.19.1.357. PMID: 10448529. Zeuschner CL, Hokin BD, Marsh KA, Saunders AV, Reid MA, Ramsay MR. Vitamin B₁₂ and vegetarian diets. Med J Aust. 2013 Aug 19;199(S4):S27-32. PMID: 25369926. Snow D. Vegetarian Diet During Pregnancy: Making Sure Vitamin B12 Intake is Adequate. MCN Am J Matern Child Nurs. 2018 Jan/Feb;43(1):53. doi: 10.1097/NMC.0000000000000400. PMID: 29215425. Rogne T, Tielemans MJ, Chong MF, Yajnik CS, Krishnaveni GV, Poston L, Jaddoe VW, Steegers EA, Joshi S, Chong YS, Godfrey KM, Yap F, Yahyaoui R, Thomas T, Hay G, Hogeveen M, Demir A, Saravanan P, Skovlund E, Martinussen MP, Jacobsen GW, Franco OH, Bracken MB, Risnes KR. Associations of Maternal Vitamin B12 Concentration in Pregnancy With the Risks of Preterm Birth and Low Birth Weight: A Systematic Review and Meta-Analysis of Individual Participant Data. Am J Epidemiol. 2017 Feb 1;185(3):212-223. doi: 10.1093/aje/kww212. PMID: 28108470; PMCID: PMC5390862. Directions: take 1 tablet a day with water.
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| Nutritional information | |
| Per daily dose (1 tablet) | |
| Vitamin B12 | 1000 μg (40 000% RI*) |
| * RI: Reference Intake |
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Ingredients: bulking agents: cellulose, dicalcium phosphate; anti-caking agents: silicon dioxide, magnesium salts of fatty acids; Vitamin B12 (methylcobalamin).
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