YAMAMOTO RESEARCH
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 YAMAMOTO® RESEARCH
Yamamoto® Research Flogorin Nowadays, nature, thanks to scientific research, provides us with nutraceutical elements with a high phytoactive activity that can contribute to joint function. Natural substances such as Curcumin and Boswellia have shown very interesting effectiveness in terms of contribution to joint function. Research has allowed us to have them in highly absorbable versions, completely natural formulations that pass easily through the intestines without activating or inhibiting Phase I and II of the liver. The presence of Ginger further favors a more effective bioavailability of all substances, since it is a powerful "bio-enhancer" of molecules.
This problem of absorption and relative bioavailability is a factor to be taken into consideration, as it is often a limitation of many active ingredients of a plant nature that are poorly absorbed in the intestine (for example Tumeric, when it is taken orally as a spice). Flogori is a food supplement based on curcuminoids, Boswellia, and ginger with a very high bioavailable power, acting in synergy and contributing together to the decisive improvement of joint functionality and physiological mobility. Turmeric rhizome has been studied worldwide in the last decade for its multiple and confirmed joint functions. Numerous authoritative studies highlight the activity of turmeric rhizomes on the joint system. Curcuminoids are the basis of this anti-inflammatory action, leading to the use of the plant by those who want to contribute to joint function. Flogorin specifically contains the very famous and most studied version "Curcugreen™ BCM-95®", obtained through a particular extraction process that involves the group of curcuminoids present in the root and the essential oils, including (Ar)-Turmerone. The number "95" that characterizes the "Curcugreen ™ BCM-95®" patent concerns the degree of standardization to 95% of the curcuminoid-essential oils complex, which allows a unique absorption and synergy of action that has demonstrated an extraordinary bioavailability from 7 to 9 times higher than that of the most common turmeric extracts at 95% standardization. This substance has a dossier of over 50 clinical studies and unique 15 years-long monitoring on quality-safety control. The turmeric in this product is GMO-free and if free from any excipient or artificial coloring. Being 100% gluten-free, Flogorin does not contain yeasts, starches, dairy products, and soy. Boswellia resin promotes joint function and counteracts localized states of tension. A gum resin rich in acids, tetracyclic acids, and polysaccharides is extracted from Boswellia, contributing to joint functionality. Flogorin contains a highly bioavailable version of Boswellia, the Biosfered patent, BosLiQ®, a highly bioavailable liquid extract with unique characteristics compared to other similar forms, characterized by the presence of acids and their esters and by the presence of high quantities of AKBA. The Ginger rhizome in the form of dry extract titrated to 5% in gingerols, further favors joint function, counteracting localized states of tension. The main constituents of the essential oil are sesquiterpene hydrocarbons (responsible for the typical aroma). Known for its pungent flavor, ginger has been studied in recent decades for its anti-nausea and digestive characteristics too. The joint and synergistic administration of these three natural elements in Flogorin significantly contributes to the normal joint function. SCIENTIFIC REFERENCES: Aryaeian N, Shahram F, Mahmoudi M, Tavakoli H, Yousefi B, Arablou T, Jafari Karegar S. The effect of ginger supplementation on some immunity and inflammation intermediate genes expression in patients with active Rheumatoid Arthritis. Gene. 2019 May 25;698:179-185. doi: 10.1016/j.gene.2019.01.048. Epub 2019 Mar 4. PMID: 30844477. Rhode, J., Fogoros, S., Zick, S. et al. Ginger inhibits cell growth and modulates angiogenic factors in ovarian cancer cells. BMC Complement Altern Med 7, 44 (2007). https://doi.org/10.1186/1472-6882-7-44 Inhibition of the NF-κB signaling pathway by the curcumin analog, 3,5-Bis(2-pyridinylmethylidene)-4-piperidone (EF31): anti-inflammatory and anti-cancer properties. Int Immunopharmacol. 2012 Feb; 12(2):368-77. J Hepatol. 2015 Sep; 63(3): 661–669. Curcumin effectively inhibits oncogenic NF-kB signaling and restrains stemness features in liver cancer Jens U. Marquardt,1,2,# Luis Gomez-Quiroz,3 Lucrecia O. Arreguin Camacho,2 Federico Pinna,4 Yun-Han Lee,1Mitsuteru Kitade,1 Mayrel Palestino Domínguez,3 Darko Castven,2 Kai Breuhahn,4 Elizabeth A. Conner,1 Peter R. Galle,2 Jesper B. Andersen,5 Valentina M. Factor,1 and Snorri S. Thorgeirsson1 J Hepatol.2004 Dec;41(6):926-34. Curcumin inhibits NF-kappaB activation and reduces the severity of experimental steatohepatitis in mice. Leclercq IA1, Farrell GC, Sempoux C, dela Peña A, Horsmans Y. Leclercq IA, Farrell GC, Sempoux C, dela Peña A, Horsmans Y. Curcumin inhibits NF-kappaB activation and reduces the severity of experimental steatohepatitis in mice. J Hepatol. 2004 Dec;41(6):926-34. doi: 10.1016/j.jhep.2004.08.010. PMID: 15582125. Siddiqui MZ. Boswellia serrata, a potential antiinflammatory agent: an overview. Indian J Pharm Sci. 2011 May;73(3):255-61. doi: 10.4103/0250-474X.93507. PMID: 22457547; PMCID: PMC3309643. Cuaz-Pérolin C, Billiet L, Baugé E, Copin C, Scott-Algara D, Genze F, Büchele B, Syrovets T, Simmet T, Rouis M. Antiinflammatory and antiatherogenic effects of the NF-kappaB inhibitor acetyl-11-keto-beta-boswellic acid in LPS-challenged ApoE-/- mice. Arterioscler Thromb Vasc Biol. 2008 Feb;28(2):272-7. doi: 10.1161/ATVBAHA.107.155606. Epub 2007 Nov 21. PMID: 18032778. Governa P, Marchi M, Cocetta V, De Leo B, Saunders PTK, Catanzaro D, Miraldi E, Montopoli M, Biagi M. Effects of Boswellia Serrata Roxb. and Curcuma longa L. in an In Vitro Intestinal Inflammation Model Using Immune Cells and Caco-2. Pharmaceuticals (Basel). 2018 Nov 20;11(4):126. doi: 10.3390/ph11040126. PMID: 30463367; PMCID: PMC6316569. Enyeart JA, Liu H, Enyeart JJ. Curcumin inhibits ACTH- and angiotensin II-stimulated cortisol secretion and Ca(v)3.2 current. J Nat Prod. 2009 Aug;72(8):1533-7. doi: 10.1021/np900227x. PMID: 19653644; PMCID: PMC2853174. Hu GX, Lin H, Lian QQ, Zhou SH, Guo J, Zhou HY, Chu Y, Ge RS. Curcumin as a potent and selective inhibitor of 11β-hydroxysteroid dehydrogenase 1: improving lipid profiles in high-fat-diet-treated rats. PLoS One. 2013;8(3):e49976. doi: 10.1371/journal.pone.0049976. Epub 2013 Mar 22. PMID: 23533564; PMCID: PMC3606385. Catanzaro D, Rancan S, Orso G, Dall'Acqua S, Brun P, Giron MC, Carrara M, Castagliuolo I, Ragazzi E, Caparrotta L, Montopoli M. Boswellia serrata Preserves Intestinal Epithelial Barrier from Oxidative and Inflammatory Damage. PLoS One. 2015 May 8;10(5):e0125375. doi: 10.1371/journal.pone.0125375. PMID: 25955295; PMCID: PMC4425476. Boswellia serrata – Scientific Review on Usage, Dosage, Side Effects … https://examine.com/supplements/boswellia-serrata/ Biol Pharm Bull. 2004 Oct;27(10):1679-82. Katagiri F, Inoue S, Sato Y, Itoh H, Takeyama M. Comparison of the effects of Sho-hange-ka-bukuryo-to and Nichin-to on human plasma adrenocorticotropic hormone and cortisol levels with continual stress exposure. Biol Pharm Bull. 2004 Oct;27(10):1679-82. doi: 10.1248/bpb.27.1679. PMID: 15467219. Directions: take 2 tablets a day with water.
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| 30 tablets |
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| Nutrition information | |
| Daily dose: 2 tablets | |
| Servings per container: 15 | |
| Per daily dose (2 tablets) | |
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Turmeric curcuminoids
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110.4 mg |
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Boswellia extract of
which boswellic acids of which AKBA |
500 mg 125 mg 25 mg |
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Ginger extract
of which gingeroli |
200 mg 10 mg |
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Ingredients: bulking agents: cellulose, dicalcium phosphate; boswellia extract BosLiq® -AKBA-PWD [dry extract of boswellia ( Boswellia sacra Fluex) gommo-resin 25% boswellic acids and 5% AKBA], dry extract of ginger ( Zingiber officinale Rosc.) rhizome 5% gingerols, total curcuminoids from turmeric Curcugreen® ( Curcuma longa L., rhizome), anti-caking agents: silicon dioxide, magnesium salts of fatty acids; coating agents: hydroxy-propyl-methylcellulose, talc, polyethylene glycol.
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