YAMAMOTO RESEARCH
Vitamina K2 + D3 60 tablets

Yamamoto® Research Vitamina K2 + D3 is a food supplement based on high-dose vitamin K2 and vitamin D3, which can be used in all cases of increased need or decreased intake of these vitamins. Vitamin D3 is essential for supporting the health of bones and teeth, supporting the immune system and preventing the onset of cardiovascular diseases, while vitamin K2 contributes to normal blood clotting and the maintenance of healthy bones.

Vitamin K2 performs various functions in our body: in particular it acts by activating MGP (Matrix Gla Protein), a protein that binds calcium circulating in the blood and prevents its precipitation in the form of crystals in the arterial wall, preventing the formation of atheromatous plaques . Furthermore, vitamin K2 stimulates osteocalcin, a protein that promotes the adhesion of calcium to bone tissue and teeth, making them more resistant and flexible. It is found in foods such as dairy products, eggs, meat and some types of leafy green vegetables.

The association with vitamin D3 makes the supplement even more effective in supporting bone and tooth health.

In fact, vitamin D is usually produced by the body following exposure to sunlight: we synthesize around 80% of the vitamin D needed through skin exposed to the sun, but it is often not possible to expose ourselves sufficiently. We spend most of our time indoors (office, school or at home) and furthermore, even food sources of vitamin D do not guarantee optimal values and, even if we tend to consider Vitamin D only for bone health, in In reality this vitamin is important for many aspects of health. It is a "parahormone" that acts on organs and systems just like a hormone. Vitamin D is essential for the skeletal system, stimulates the absorption of calcium and phosphorus and is essential for maintaining good bone and tooth health. Vitamin D is found in almost 3,000 genes of the body and its receptors throughout the body: it therefore becomes clear how this micronutrient is implicated in many processes linked to our well-being.  

What are the symptoms of Vitamin D deficiency? What about Vitamin K?
Vitamin D deficiency can cause a number of symptoms and health problems, including:

• Muscle weakness;
• Muscle and joint pain;
• Tiredness and fatigue;
• Reduced wound healing ability;
• Depression;
• Loss of bone density and osteoporosis;
• Increased risk of bone fractures;
• Reduced ability of the immune system to fight infections.
• Additionally, vitamin D deficiency may be related to an increased risk of certain chronic diseases.
• However, vitamin K deficiency can cause:
• Osteoporosis or bone fragility;
• Arterial calcification;
• Excessive bleeding and weak teeth;
• Problems growing up.

Per whom is taking Vitamin D3 50 μg recommended?
Taking vitamin K2 + D3 may be advisable for several categories of people, including:

• People with an increased risk of osteoporosis or bone fractures, such as menopausal women, older adults, or people with conditions that can weaken bones.
• People with an increased risk of cardiovascular disease, such as people with risk factors such as high blood pressure, high cholesterol or diabetes.
• People with intestinal malabsorption or conditions that can interfere with the absorption of nutrients.
• People following restrictive or vegetarian/vegan diets, who may not get enough of the necessary amounts of vitamin K2 and D3.

What changes between vitamin D and vitamin D3? They are the same thing?
The main difference between vitamin D and vitamin D3 is their origin and chemical form.
Vitamin D is in fact a fat-soluble vitamin that exists in two main forms: vitamin D2 (ergocalciferol) and vitamin D3 (cholecalciferol). Vitamin D2 is found primarily in plant sources, while vitamin D3 is found in animal sources and is produced naturally by the skin in response to UVB sunlight.
Vitamin D3 is considered the most effective form of vitamin D, as it has a greater affinity for vitamin D receptors in the body and is converted into the active form more easily than vitamin D2. Additionally, vitamin D3 supplements are generally more effective at increasing blood vitamin D levels than vitamin D2.

What changes between vitamin K and K2? What is the difference?
Vitamin K2, or menaquinone, is a fat-soluble vitamin, belonging to the vitamin K family. This family of vitamins includes:

• vitamin K1, phylloquinone, which is found in plants and is then converted into K2 (it is therefore the least effective form, because it must be transformed into the active form to ensure significant action);
• vitamin K2, which exists in two forms: MK-4 (in meat, eggs and dairy products) and MK-7 (in grass-fed meat, fermented soybeans, yogurt and kefir) and is more bioavailable and rapidly used by the body ;
• vitamin K3, of synthetic origin and useful for regulating blood coagulation.

The K2 MK-7 form is therefore the optimal one for the formulation of food supplements, natural and highly bioavailable.

Scientific references

Knapen MHJ, Drummen NE, Smit E, et al. Three-year low-dose menaquinone-7 supplementation helps decrease bone loss in healthy postmenopausal women. Osteoporos Int. 2013 Sep;24(9):2499-507. doi: 10.1007/s00198-013-2325-6. Epub 2013 Mar 23. PMID: 23525894.

Vermeer C, Braam L. Role of K vitamins in the regulation of tissue calcification. J Bone Miner Metab. 2008;26(9):73-79. doi: 10.1007/s00774-008-0020-6. PMID: 18648931.

Shea MK, Booth SL, Massaro JM, et al. Vitamin K and vitamin D status: associations with inflammatory markers in the Framingham Offspring Study. Am J Epidemiol. 2008 Dec 1;168(11):1169-78. doi: 10.1093/aje/kwn224. Epub 2008 Oct 9. PMID: 18845877; PMCID: PMC2727204.

Beulens JW, Bots ML, Atsma F, et al. High dietary menaquinone intake is associated with reduced coronary calcification. Atherosclerosis. 2009 Apr;203(2):489-93. doi: 10.1016/j.atherosclerosis.2008.07.010. Epub 2008 Jul 19. PMID: 18722618.

Shiraki M, Shiraki Y, Aoki C, et al. Vitamin K2 (menatetrenone) effectively prevents fractures and sustains lumbar bone mineral density in osteoporosis. J Bone Miner Res. 2000 Mar;15(3):515-21. doi: 10.1359/jbmr.2000.15.3.515. PMID: 10713906.